Air Pollution Thickens the Blood
PM10 particles thicken the blood and boost inflammation, according to the results of an experimental study.
Scientists tested the inflammatory and blood clotting responses of human lung cells, cells taken from the umbilical cord, and immune cells called macrophages. Each was tested six and 24 hours after exposure to particulate matter. The results showed that levels of clotting factors, which thicken the blood, were elevated in several of the cell types. The rate of death in immune cells also increased significantly, and exposure to PM10 boosted inflammatory activity.
Researchers concluded that “PM10 has the ability to alter macrophage, epithelial, and endothelial cell function to favour blood coagulation via activation of the extrinsic pathway and inhibition of fibronolysis pathways.” This suggests a mechanism for the adverse cardiovascular effects caused by inhalation of particulate matter.
Gilmour PS, Morrison ER, Vickers MA, Ford I, Ludlam CA, Greaves M, Donaldson K, MacNee W. The Procoagulant Potential of Environmental Particles (PM10). Occup Environ Med 2005; 62:164-171.
For a copy of the abstract click here.
